2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Thyroid Hormone Receptor

Thyroid Hormone Receptor

THR

Thyroid Hormone Receptor

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Thyroid hormone receptor is a member of the nuclear receptor superfamily that shuttles between the cytosol and nucleus. Thyroid hormone receptors are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Thyroid hormone receptors are encoded by two genes, one for TRα and another for TRβ, which encode the major isoforms of TR, including TRα1, TRα2, TRβ1, and TRβ2. The thyroid hormone receptors mediate the pleiotropic activities of the thyroid hormone (T3) in growth, development, and differentiation and in maintaining metabolic homeostasis.

Thyroid hormone receptors are zinc finger transcription factors in the erbA superfamily that bind DNA at specific response element sequences (thyroid hormone response elements, TREs) and activate gene expression in response to thyroid hormone (T3). Thyroid hormone receptors have been shown to bind DNA as monomers, homodimers, or heterodimers with another erbA superfamily member, the retinoid X receptor (RXR).

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P1252A
    Parathyroid Hormone (1-34), bovine TFA
    		Agonist
    Parathyroid Hormone (1-34), bovine TFA is a potent parathyroid hormone (PTH) receptor agonist. Parathyroid Hormone (1-34), bovine increases calcium and inorganic phosphate levels in vivo. Parathyroid Hormone (1-34), bovine can be used for th reseach of osteoporosis.
    Parathyroid Hormone (1-34), bovine TFA
  • HY-149218
    THR-β agonist 6
    		Agonist
    THR-β agonist 6 is an orally active, selective thyroid hormone receptor β (THR-β) agonist with EC50s of 0.03 μM and 0.22 μM for THR-β and THR-α, respectively. THR-β agonist 6 exhibits an xcellent liver-to-serum ratio of 93:1 in mice. THR-β agonist 6 has the potential for nonalcoholic steatohepatitis (NASH) research.
    THR-β agonist 6
  • HY-P4690
    pTH (13-34) (human)
    pTH (13-34) (human) is apTH ((Human parathyroid hormone) fragment.
    pTH (13-34) (human)
  • HY-162999
    TRIP13-IN-1
    		Inhibitor
    TRIP13-IN-1 (compound 20) is a potent ligand and inhibitor of TRIP13, demonstrating anti-cancer effects both in vitro and in vivo.
    TRIP13-IN-1
  • HY-P0059A
    Teriparatide acetate hydrate
    		Agonist
    Teriparatide acetate hydrate (Human parathyroid hormone-(1-34) acetate hydrate) is a PTH1 receptor agonist. Teriparatide acetate hydrate (Human parathyroid hormone-(1-34) acetate hydrate) can be used for osteoporosis research.
    Teriparatide acetate hydrate
  • HY-P4818
    Human PTH-(1-31) amide
    Human PTH-(1-31) amide is a PTH analog. Human PTH-(1-31) amide stimulate phosphatidylcholine hydrolysis and stimulates adenylyl cyclase release.
    Human PTH-(1-31) amide
  • HY-115434
    3,5-Diiodothyroacetic acid
    3,5-Diiodothyroacetic acid is a thyroid hormone analog. 3,5-Diiodothyroacetic acid lowers blood cholesterol concentrations. 3,5-Diiodothyroacetic acid can be used for hypothyroidism diseases research.
    3,5-Diiodothyroacetic acid
  • HY-171013
    THR-β agonist 8
    		Agonist
    THR-β agonist 8
  • HY-P3969
    Prepro-TRH-(160-169)
    		Agonist
    Prepro-TRH-(160-169) is one of the connecting peptides of thyrotropin-releasing hormone prohormone (pro-TRH), potentiates TRH-induced thyrotropin (TSH) release.
    Prepro-TRH-(160-169)
  • HY-19154
    Montirelin
    Montirelin (NS 3) is an analog of thyrotropin-releasing hormone (TRH), and exhibits high affinity to TRH receptors. Montirelin exhibits potent effects to central nervous system (CNS).
    Montirelin
  • HY-P4857
    pTH-Related Protein (7-34) amide (human, mouse, rat)
    pTH-Related Protein (7-34) amide (human, mouse, rat) is a potent antagonist of parathyroid hormone (PTH).
    pTH-Related Protein (7-34) amide (human, mouse, rat)
  • HY-111983
    Etiroxate
    		Agonist
    Etiroxate (CG-635) is a lipid lowing compound which can be used for hyperlipoproteinemia research.
    Etiroxate
  • HY-A0070AS1
    Liothyronine-13C9,15N
    Liothyronine-13C9,15N is the 13C and 15N labeled Liothyronine[1]. Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[2][3][4].
    Liothyronine-<sup>13</sup>C<sub>9</sub>,<sup>15</sup>N
  • HY-147500
    TRβ agonist 2
    		Agonist
    TRβ agonist 2 (Compound 1) is a potent agonist of TRβ. TRβ agonist 2 reduces lipid accumulation in HepG2 and promote lipolysis with comparable effects. TRβ agonist 2 is a new potential TRβ-selective thyromimetics.
    TRβ agonist 2
  • HY-18341BR
    L-Thyroxine (sodium) (Standard)
    L-Thyroxine (sodium) (Standard) is the analytical standard of L-Thyroxine (sodium). This product is intended for research and analytical applications. L-Thyroxine sodium (Levothyroxine sodium) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
    L-Thyroxine (sodium) (Standard)
  • HY-P4700
    pTH (53-84) (human)
    pTH (53-84) (human) is apTH ((Human parathyroid hormone) fragment.
    pTH (53-84) (human)
  • HY-153535
    THRβ receptor agonist-1
    		Agonist
    THRβ receptor agonist-1 is a THRβ receptor agonist.
    THRβ receptor agonist-1
  • HY-125787
    MLS000389544
    		Antagonist
    MLS000389544 is a selective and potent methylsulfonylnitrobenzoate thyroid hormone receptor β (TRβ) antagonist that blocks the association of TRβ with steroid receptor coactivator 2 (SRC2).
    MLS000389544
  • HY-W010696AS
    Reverse T3-13C6 hydrochloride
    Reverse T3-13C6 (hydrochloride) is the 13C labeled Reverse T3[1].
    Reverse T3-<sup>13</sup>C<sub>6</sub> hydrochloride
  • HY-153637
    THR-β modulator-1
    		Modulator
    THR-β modulator-1 (compound 1a) is a potent thyroid hormone receptor β modulator. THR-β modulator-1 can be used in research of thyroid hormone receptor related disorders.
    THR-β modulator-1
Cat. No. Product Name / Synonyms Application Reactivity